glp 1 and eye disease Diabetes Weight Loss Drugs May Double Risk of Macular Degeneration The protective role of GLP-1

Kyriacou A, Ahmed AB

Interestingly, this reduced movement phenotype can be restored by blocking the GLP-1R pharmacologically or by disrupting subdiaphragmatic vagal signaling [123]

doi: 10.1515/hmbci-2021-0065 173 RebarRW

Most importantly, this protective phenotype appears to involve the following beneficial cellular adaptions: (i) enhanced metabolism of ethanol and acetaldehyde, (ii) suppression of lipogenic genes and induction of genes involved in fatty acid oxidation, and (iii) induction of the NRF2 antioxidant response and the AMPK metabolic signaling pathway

When you take them together, you are essentially providing the building blocks and the tools at the same time